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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika Medical Laboratory Technology Journal Jurnal Gizi Klinik Indonesia JBN (Jurnal Bedah Nasional) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Community Empowerment for Health JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Tri Ratnaningsih
Clinical Pathology Departement, Medicine Public Health And Nursing Faculty, Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Iron deficiency screening with content hemoglobin reticulocyte (chr) in children aged 6 months to 5 years Dea Noviana Pramantik; Tri Ratnaningsih; Budi Mulyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 3 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.082 KB) | DOI: 10.19106/JMedSci004703201501

Abstract

Anemia is a major health problem around the world and iron deficiency is the major cause. In children under 5 years old iron deficiency cause disruption in their growth and development. For that reasons iron deficiency in children should be detected as early as possible. The gold standard for the detection of iron deficiency is hemosiderin examination from bone marrow aspiration, but this examination is invasive and difficult to implement. Ferritin is often used to detect iron deficiency but it has various limitations. Reticulocyte hemoglobin content (CHr) was introduced as a new parameter for the identification of iron deficiency. This parameter measures the levels of hemoglobin in the reticulocyteswhich is newly released from bone marrow and expected to reflect the actualconditions in the bone marrow, therefore it can detect early iron deficiency. It is expected that CHr can identify iron deficiency with cheaper, easy, and applicative method. The aim of this study was to determine the diagnostic performance of CHr in screening of iron deficiency in children aged 6 months to 5 years old. The present study was a cross sectional study to determine the diagnostic performance of CHr and use ferritin as gold standard. The subjects of this study were healthy children aged 6 months-5 years old taken from Posyandu in Yogyakarta district and previously had obtained the consent of their parent/guardian. The CHr examination used a flowcytometry method by Advia120 Hematology Analyzer. The ferritin examination used an electrochemiluminescens method with Elecsys 1010. ROC curve analysis was performed using SPSS version 17. The sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and likelihood ratio were calculated using a 2x2 TABLE. Youden’s index was used to choose the proper cutoff level of CHr for diagnosing iron deficiency. The study was conducted on 104 subjects. Cutoff level of CHr was ≤27.65 pg and the sensitivity, specificity, diagnostic accuracy, positive, and negative predictive values were 91.7%,78.3%, 79.8%, 35.4%, 98.63% respectively. Positive and negative results of likelihood ratios were 4.21 and 0.1. CHr is expected to be used to screen iron deficiencyin children under 5 years old.
Prognostic factors for mortality in patients with severe traumatic brain injury in Yogyakarta, Indonesia Desin Pambudi Sejahtera; Ismail Setyopranoto; Indarwati Setyaningsih; Sri Sutarni; Tri Ratnaningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 2 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.986 KB) | DOI: 10.19106/JMedSci005202202003

Abstract

Determining an accurate prognosis in patients with severe traumatic brain injury (TBI) still becomes a difficult challenge for neurologists. Clinical and laboratory findings have been used as important parameters to establish clinical decisions or even predict future prognosis including death in these patients. We studied the clinical, laboratory and neuroimaging parameters in predicting mortality in patients with severe TBI. This study used the medical records of severe TBI cases in Dr. Sardjito General Hospital, Yogyakarta, Indonesia from January 2015 until July 2016. We evaluated the clinical, laboratory, and neuroimaging examinations of seventy patients with severe TBI in association with mortality. The result showed among 70 patients involved, 35 were dead. Clinical findings of age <40 y.o. (OR=1.143; p=0.015), multiple injuries (OR=5.712; p=0.045), and systolic blood pressure >140 mmHg (OR=3.852; p=0.008) were associated with mortality. Laboratory and neuroimaging parameters of hyponatremia (OR=3.667; p=0.027), hyperkalemia (OR=1.771; p=0.030), and the presence of traumatic subarachnoid hemorrhage (SAH) (OR=6.526; p=0.003) in head CT-scan were significantly associated with mortality. In conclusion, our study showed that productive age <40 y.o. multiple injuries, hyponatremia, hyperkalemia and the presence of traumatic SAH increase the mortality risk in patients with severe TBI.
Co-Authors Abdul Wahab Ainun Nisa Aji Bagus Widyantara Arta Farmawati Arum Tri Wahyuningsih Bambang Sasangka Budi Mulyono Budiatri Retno Noormaningrum Bunga Fatimah Busyra Busyra Dea Noviana Pramantik Desin Pambudi Sejahtera Elizabeth Henny Herningtyas Emy Huriyati Fardhiasih Dwi Astuti Fuad Anshori Indarwati Setyaningsih Ismail Setyopranoto Maria Agnes Etty Dedy Maria Agnes Etty Dedy marsa, mardhatillah Moch Junaidy Heriyanto Nasution, Annio Indah Lestari Nur Imma Fatimah Harahap Purbosari Purbosari Rahmat Dani Satria Rona Hafida Heriyanto Putri Setyawati Setyawati Sri Sutarni Suhartini Suhartini Suhartini Suhartini Suhartini Suhartini Teguh Triyono Teguh Triyono Usi Sukorini Wirimena Hurimah Yudha Nurhantari Yudha Nurhantari Yudha Nurhantari